A process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein.

摘要

Disclosed is a process for the preparation of a compound of the general formula
<CHEM>
wherein R<1> is, e.g.,
<CHEM>
wherein Q is
<CHEM>
or R<6> - @@; R<6> is H or OH; and R is hydrogen or methyl, and a and c or b and d represent double bonds or all of a, b, c, and d are single bonds comprising:
(A) reacting a compound of the formula
<CHEM>
wherein R<5> and R<7> are, e.g., C1-5 alkyl, with a compound of the formula;
R<1>X      (III)
wherein X, e.g., is a metal atom to afford a compound of the formula
<CHEM>
(B) lactonizing the compound of the formula (IV) under standard acidic conditions to afford the compound of formula
<CHEM>
and (C) removing the R<7> group with an organoborane halide.