3A,4,7,7a-tetrahydro-3,6,7a-trimethyl-4-substituted phenyl-isoxazolo[5,4-b]pyridine-5-carboxylic acid esters

摘要

Disclosed herein are 4-phenyl-tetrahydro-isoxazolo[5,4-b]-pyridine-5-carboxylic acid esters of Formula I: <IMAGE> wherein Ar is phenyl or phenyl substituted by a halogen, nitro, or trifluoromethyl group; R1 is C1-3 alkyl; and R2 is C1-5 alkyl, (C1-5) alkoxy (C1-3)-alkyl, or mono- or di(C1-5) alkylamino (C1-3)alkyl; or physiologically acceptable acid addition salts thereof. The compounds of the invention exhibit calcium antagonist and antihypertensive properties in standard pharmacological procedures.