发明名称 |
PHARMACOLOGICAL MEDICINE CONTAINING IBUPROFEN AND MANUFACTURE |
摘要 |
A pharmaceutical preparation containing ibuprofen is disclosed. In the preparation, the ibuprofen particles are enveloped by a coating of a hydro-colloid and fumaric acid. Preferably, the hydro-colloid comprises xanthan gum and/or maltodextrin. This preparation reduces the tendency of ibuprofen to irritate the esophagus and the gastrointestinal tract when taken orally. An effervescent mixture of the ibuprofen containing preparation can be prepared by incorporating citric acid and calcium carbonate into the mixture. A process for the manufacture of the ibuprofen containing preparation is also disclosed. In this process, ibuprofen particles are coated with the hydro-colloid and fumaric acid under vacuum conditions in a vacuum mixing machine and the resulting preparation is thereafter vacuum-dried. |
申请公布号 |
JPS61115023(A) |
申请公布日期 |
1986.06.02 |
申请号 |
JP19850243015 |
申请日期 |
1985.10.31 |
申请人 |
GERUHARUTO GERUGERII |
发明人 |
GERUHARUTO GERUGERII;TOOMASU GERUGERII;IRUMUGARUTO GERUGERII |
分类号 |
A61K9/00;A61K9/16;A61K9/20;A61K9/30;A61K9/46;A61K9/50;A61K31/12;A61K31/19;A61K31/195;A61K31/198;A61K31/38;A61K31/40;A61K31/43;A61K31/70;A61K47/12;A61K47/26;A61K47/36;A61P29/00;B01J13/02 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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