| 摘要 |
<p>A compound of formula I <CHEM> in which formula R<1> and R<2>, which may be the same or different, each represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms or, together with the nitrogen atom to which they are attached, R<1> and R<2> form a 4 to 8-membered ring which may contain an oxygen atom or another nitrogen atom, which nitrogen atom may have an alkyl group having in from 1 to 4 carbon atoms as substituent. X represents an oxygen atom or a group NR<4> in which R<4> represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms, a phenyl group or a phenalkyl group, the alkyl moiety of which has from 1 to 4 carbon atoms. an alkyl, phenyl or phenalkyl group being unsubstituted or substituted, or R<4> represents a nitrogen protecting group; m represents an integer of from 1 to 4; n represents the integer 1 or 2; and R<3> represents a group of formula II, III, IV, V or VI <CHEM> in which formulae R<5> represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms; and R<6> represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, an alkenyl group having from 2 to 4 carbon atoms, or an alkynyl group having 3 or 4 carbon atoms has histamine H-2 antagonist activity, and may be used to produce medicaments.</p> |
