摘要 |
1-(1-(4-Diphenylmethyl piperazinyl)) 3-(1-(1,3-dihydrobenzo 1,3-diazolyl-2-one))propane is made by (a) reacting 4-diphenyl-methyl piperazine with a 1,3-dihalopropane under liquid-liquid phase transference conditions, using as aq. phase a soln. of an alkali or alkaline earth hydroxide, carbonate or bicarbonate, and as organic phase a lipophilic solvent immiscible with water in presence of an ammonium or phosphonium quat. salt as catalyst, to give a cpd. of formula (II), in which Z is Cl or Br; or (b) under solid-liquid phase transference conditions with a polar or apolar solvent and finely-powdered alkali metal hydroxide as solid phase; and (c) treating the prod. from (a) or (b) with 1,3-dihydrobenzo 1,3-diazoloyl-2-one.
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