| 摘要 |
<p>1-Pyridyl-indole derivs. of formula (I), their pyridyl N-oxides, and their salts are claimed. In (I), Ar = opt. lower alkyl-substd. 3- or 4-pyridyl; R1 = H, halogen, CF3, lower alkyl, OH, acyloxy, etherified OH, lower alkylthio, lower alkylsulphinyl and/or lower alkylsulphonyl, or two adjacent residues R1 can form an alkylenedioxy gp.; p = 1 or 2; R2 = H or lower alkyl; R3, R4 = H or -A-B, at least one (but not both) being H; A = 1-12C alkylene, 2-12C alkynylene or alkenylene, lower alkylenephenylene, lower alkylene-(thio or oxy)-lower alkylene, (lower alkylene) -phenylene-(lower alkylene or alkenylene) or alkadienylene with 4-12C atoms; B = COOH, esterified carboxy, CONH2, mono- or di-(lower alkyl)carbamoyl, CN, hydroxycarbamoyl, 5-tetrazolyl or opt. lower alkyl-substd. 4,5-dihydro-2-oxazolyl. - Specifically claimed are 11 cpds., including 3-(4-carboxybutyl) -N-(3-pyridyl)indole and (E)-3-(4-carboxy-3-pentenyl) -N-(3-pyridyl)indole.</p> |
