New GnRH antagonist peptide(s)

摘要

Peptides of formula (I) and their salts are new. X-R1-R2-R3-Ser-R5-R6-R7-Arg-Pro-R10 (I) X=H, acryloyl or MeCO; R1=beta-D-2-naphthylalanyl, dehydro-Pro or 4-chloro-D-Phe; R2=Cl-D-Phe, F-D-Phe or C(alpha)-Me-Cl-D-Phe; R3=D-Trp- or beta-D-2-naphthylalanyl; R5=Arg or D-Arg; R6=D-Tyr, beta-D-2-naphthylalanyl or D-Arg; R7= Leu or NML; R10=Gly-NH2, NHEt or D-Ala-NH2.