摘要 |
<p>Novel esters of 9 alpha -fluoro- and chloro-corticosteroids of the formula <IMAGE> wherein Y is chlorine or OR1, R1 and R2 represent an acyl group of 2-6 carbon atoms or a benzoyl group and where R1 and R2 can be the same or different in the same molecule, R3 is methyl or fluorine in either the alpha - or beta - orientation, X is chlorine or fluorine, and the C1 C2 bond can be saturated or not, especially those compounds of the formula <IMAGE> wherein Y and R2 have the significance given above, are prepared by reacting the respective 9 beta ,11 beta -epoxy compounds with hydrogen fluoride or chloride.</p> |