| 摘要 |
<p>Compounds are disclosed having the formula <CHEM> R1 is hydrogen, benzyl or an ester moiety; Y is -CH(R2 sec )CH(R2)- or -CH(R3)CH2-; R2 sec is hydrogen or methyl; R2 is OH or X-substituted (C1-6)alkyl; R3 is OH, cyano or X-substituted (C1-3)alkyl; X is -OR6, -SR6, -S(O)R6, -S(O)2R6, -NR6R7, -COOR7, -CONR7R8 or oxo; with the proviso that when X is -NR6R7, -COOR7 or -CONR7R8, said group is located on the terminal carbon atom of R2 or R3; R6 is hydrogen, (C1-6)alkyl or acetyl, with the provisos that, when R6 in -NR6R7 is acetyl, R7 is hydrogen, and R6 in S(O)R6 and S(O)2R6 cannot be acetyl; each of R7 and R8 is hydrogen or (C1-6)alkyl; s is an integer of 1 or 2; and Z-W is alkyl or oxaalkyl having 5 to 13 carbon atoms, or phenyl- or pyridyl-alkyl or -oxaalkyl having 3 to 8 carbon atoms in the alkyl or oxaalkyl group. Pharmaceutical compositions of such compounds, other than those in which <CHEM> is mandeloyl or R1 is benzyl, are useful as analgesic or CNS agents and as anti-emetic agents.</p> |
