| 摘要 |
PURPOSE:A preventive for dental caries having an inhibitory action on formation of bacterial plaque for a long period, obtained by immunizing an animal against the whole mold or a mold component of Streptococcus mutans to give an antibody, and blending a preventive for dental caries with it and a nonionic surface active agent. CONSTITUTION:An animal is immunized against the whole mold or a mold component (e.g., cell wall fraction) of Streptococcus mutans, preferably a strain or a mutant (e.g., K-Dp type, or KH2 strain) of human type Streptococcus mutans whose serum type is c, d, e, f, or g type, as an antigen, to give an antibody. A preventive for dental caries is blended with the antibody and a nonionic surface active agent (e.g., fatty acid alkanolamide). The antibody suppresses formation of bacterial plaque has preventing effect on dental caries, and addition of the nonionic surface active agent keeps stably the antibody in the preventive for dental caries for a long period. An amount of the surface active agent blended is 0.1-3wt% based on the total amounts of the preventive for dental caries.
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