摘要 |
<p>A dihydropyridine of the formula: <CHEM> wherein R<1> is alkyl or alkoxyalkyl, wherein R<2> and R<3> each is alkyl, wherein R<4> is alpha-branched-chain alkyl, hydroxyalkyl, arylalkyl or aryloxyalkyl, or acylaminoalkyl, wherein benzene ring A bears one or more substituents selected from halogeno, cyano, nitro, trifluoromethyl and alkyl or bears the substituent =N-O-N= attached to the 2- and 3-positions, wherein Ar is phenylene, naphthylene, tetrahydronaphthylene, indanylene or pyridylene which is unsubstituted or which bears one or more substituents; wherein p is 0 or 1; wherein X is -O- or -NH-; wherein X<1> is a direct link or is -O-, -S-, -NH- or -NHSO2-; and wherein Y is straight- or branched-chain alkylere which may optionally be interrupted by one or two groups selected from oxygen, sulphur, imino, substituted imino, phenylene, substituted phenylene, pyridylene, cycloalkylene, 1,4-piperazinediyl, 1,3- or 1,4-piperidinediyl and amido groups; or an acid-addition salt thereof, processes for their manufacture and pharmaceutical compositions containing them. The compound possess either beta-adrenergic blocking or calcium ion slow channel blocking properties, or both such properties, and may be used in the treatment of hypertension.</p> |