| 摘要 |
Compounds having the formula: …<CHEM>… in which:… … … P is Phe, Ile, Phe(4'-Alk), Tyr or Tyr(Alk); … X is a D or L isomer of Val, Nva, Leu, Ile, Pba, Phe, Phe(4'-Alk), Trp, Nle, Cha, Abu, Met, Chg, Tyr or Tyr(Alk); … Y is Val, Ile, Abu, Ala, Chg, Gln, Lys, Cha, Thr, Nle, Phe, Leu or Gly; … Z is a D or L isomer of Arg, Harg, Leu, Lys or Orn; … A is Gly(NH2), Gly, Gly(NH-Alk), OH, NH2 or NHAlk; and … R is, each, hydrogen or methyl; … or a pharmaceutically acceptable salt thereof, which have V1-vasopressin antagonist activity and which are useful in the treatment of hypertension, shock and cardiac insufficiency. |
