| 摘要 |
NEW MATERIAL:The compound of formula I (R is H, lower alkyl, etc.; R' is H or N-protecting group; R' is methyl, halogenomethyl, hydroxymethyl, formyl, carboxyl, lower alkoxycarbonyl, etc.). EXAMPLE:4-(1-Methylethenyl)-3-(1-benzyloxycarbonyloxyethyl)-1-di(p-ani syl)me thyl-2-azetidinone. USE:A synthetic intermediate of antibacterial agent. It enables the stereoselective introduction of especially 1-methyl group by using as an intermediate in the production of a 1- methylcarbapenem compound. PREPARATION:The beta-lactam compound of formula III is prepared by dehydrating the beta-lactam compound of formula II (R1 is H, lower alkyl or OH-protected 1-hydroxy-lower alkyl) in the presence or absence of a base. |
