发明名称 |
PROCESS FOR PRODUCING 7-OXO-4-THIA-1-AZABICYCLO/3.2.0/HEPT-2-ENE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS ACTIVE AGENTS |
摘要 |
<p>A compound of formula I <IMAGE> (I) with R1 being an alkyl group substituted by one or more substituents and esters thereof at the 2-carboxy group or at the 8-hydroxy group or both; and salts thereof. Compounds I have antibacterial effect. Various intermediates are described. This compound of the formula I, or an ester at the 2-carboxy group or at the 8-hydroxy group or both or a salt thereof is produced by reacting a compound of formula II or of formula IX <IMAGE> II <IMAGE> IX in which R represents a hydrogen atom or a carboxy protecting group, R3 represents an activated carboxylic acid group, R4 represents an alkyl group having 1 to 4 carbon atoms, or a phenyl group which may be unsubstituted or substituted, R15 represents a phenyl group or an alkyl group having from 1 to 4 carbon atoms, and X represents an oxygen or sulphur with an amine of the formula III R1NH2 (III) to give a compound of formula I, or an ester thereof of formula Ia <IMAGE> (Ia)</p> |
申请公布号 |
HUT38353(A) |
申请公布日期 |
1986.05.28 |
申请号 |
HU19850003354 |
申请日期 |
1985.09.05 |
申请人 |
HOECHST AG LTD.,GB |
发明人 |
BARKER,ANDREW J.,GB;CARRUTHERS,NICHOLAS I.,GB;COOKE,MICHAEL D.,GB |
分类号 |
C07D205/08;C07D205/09;C07D499/00;C07D499/88;C07F7/18;(IPC1-7):C07D499/00;A61K31/43 |
主分类号 |
C07D205/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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