3-BICYCLICPYRIDINIUM-METHYL CEPHALOSPORINS

摘要

Cephalosporin compounds substituted in the 7-position by a 2-(5- or 6-membered heterocyclic)-2-oximinoacetylamino group and of the formula in which R is hydrogen, formyl, alpha -aminoadipoyl, protected alpha -aminoadipoyl, or an acyl group of the formula in which R min is a 5- or 6-membered heterocyclic ring of the formulae R sec is hydrogen, C1-C4 alkyl, a carboxy-substituted alkyl or carboxy-substituted cycloalkyl group of the formula: in which n is 0-3; a and b when taken separately are, independently, hydrogen or C1-C3 alkyl, and when taken together with the carbon to which they are bonded form a C3-C7 carbocyclic ring; R''' is hydrogen, C1-C4 alkoxy, amino, or OR<0>, in which R<0> is indanyl, phthalidyl or an acyloxymethyl group of the formula -CH2-O-C(O)-R2 in wich R2 is C1-C4 alkyl or phenyl; or COOR<0> is a protected carboxy group; or R sec is an N-substituted carbamoyl group of the formula -@-NHR sec sec in which R sec sec is C1-C4 alkyl, phenyl or C1-C3 alkyl substituted by phenyl; Y and m, independently, are integers equal to 0, 1, 2 or 3, provided that y plus m equals 3; R<1> is hydrogen, C1-C4 alkyl, phenyl, thienyl, amino or C1-C4 alkanoylamino; X is O, S or N-R<2>, where R<2> is hydrogen or C1-C4 alkyl; or a pharmaceutically-acceptable salt or biologically-cleavable ester thereof.