PROCESS FOR PREPARING N-NAPHTHOYL-GLYCINE DERIVATIVES

摘要

Herein disclosed are N-naphthoylglycine derivatives having aldose reductase inhibiting activity. The derivatives are useful for treating diabetic complications. The derivatives are of the formula (where R<1> is hydrogen lower alkyl, lower alkenyl or phenylmethyl, R<2> is hydrogen or lower alkyl and R<3>, R<4> and R<5> are hydrogen or specified substituents) and therapeutically acceptable salts of the compounds wherein R<2> is hydrogen. Certain intermediate aminoacids useful in the preparation of the above mentioned derivatives also have aldose reductive inhibiting effects.