GERANYLGERANYLACETAMIDE COMPOUNDS HAVING A PIPERAZINE RING, SALTS THEREOF, PROCESS FOR PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS, AND METHOD OF TREATING ULCERS IN MAMMALS

摘要

A geranylgeranylacetamide compound having a piperazine ring represented by the following formula (I) (I) wherein R represents a member selected from the class consisting of a hydrogen atom, C1-C5 alkyl groups which are unsubstituted or mono-substituted by a halogen atom, C2-C5 alkenyl groups and C7-C8 aralkyl groups, R1 represents a C1-C3 alkyl group, and n represents 0, 1 or 2, and a pharmaceutically acceptable acid addition salt thereof. The aforesaid compound can be prepared by reacting geranylgeranylacetic acid or its reactive derivative with a piperazine compound, and thereafter, if desired, transforming the free geranylgeranylacetamide compound thus obtained into its pharmaceutically acceptable acid addition salt. A pharmaceutical composition containing said compound exhibits antiulcerogenic activity, particularly excellent antipeptic ulcerogenic activity, and is useful as an agent for treating ulcers.