| 摘要 |
Fluorescent indicator dyes for calcium ions of the formulae: <CHEM> or <CHEM> wherein R<1> is -H, -CH3, -F, -Cl or -Br; R<2> is -H, -CH3, -F, -Cl, -Br, or C1-C4 alkoxy; R<3> and R<3a> are independently H or -CO2H, -CO2R<4>, -CONR<5>R<6>, -SO3H, -SO2NR<5>R<6>, -SO2CF3, -COCH3, or -CN, or R<3> and R<3a> together are -(CO)NR<5>(CO)-; R<4> is alpha-acyloxyalkyl or a physiologically acceptable esterifying group; R<5> and R<6> are independently -H, methyl, or ethyl; Z is an aromatic or heteroaromatic system coupled to the 5 position of one 2-aminophenoxy ring through a trans ethylenic linkage, wherein the ethylenic linkage may itself be part of an aromatic or heteroaromatic ring system; W is H and X is H; or W and X together are O, or NR<5>; Y is H; Y min is H (unless A is NR<5>, O, or S); or Y and Y min together are NR<5> and A is C; A and A min are independently C, N, O, or S; D is O, N, NH, or N alkyl; Q is a double bond when D is N and a single bond otherwise; and R<7> is H and R<8> is H or R<7> and R<8>, together with heteroatom D, the carbon adjacent R<7>, and the phenyl ring adjacent to R<8>, form a quinoline ring system (D=N, Q=double bond). |
