New 2-phenyl bi:cyclic imidazole derivs.

摘要

2-Phenyl-imidazole derivs. of formula (I) and their tautomers, and acid addition salts of these cpds.: A,B,C,D=NH, N-(1-3C alkyl), CH, a C-atom substd. by halogen, OH, benzyloxy or 1-3C alkoxy, or CO, provided that at least one of A,B,C, and D is NH or N-(1-3C alkyl) and at least one is CO or a C-atom substd. by OH, benzyloxy or alkoxy; R1=e.g. CN, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonyl or alkanoylamino; or, when the molecule is other than an 8-phenyl-xanthine molecule in which the phenyl ring is unsubstd. in the 2- and/or 6-position, aminosulphonyl, alkylaminosulphonyl or dialkylaminosulphonyl; or, when A is NH or N-alkyl, also 1-3C alkylmercapto, alkylsulphinyl or alkylsulphonyl; or, when A is NH or N-alkyl and the phenyl ring is substd. in the 2-position by an alkoxy or dialkylamino group, also halogen, 1-3C alkyl, NO2, COOH, NH2, 1-3C alkylamino, di(1-3C alkyl)amino, benzyloxy, or 1-3C alkoxy in the 4- or 5-position; or, when A is NH or N-alkyl and R2 and R3 are other than H, also halogen, NO2, SO3H or 1-3C alkyl; or, when A and at least one of B and D are NH or N-alkyl, also halogen, 1-3C alkyl, OH, benzyloxy, 1-3C alkoxy, 1-3C alkylmercapto, 1-3C alkylsulphinyl, 1-3C alkylsulphonyl, SO3H, NO2, NH2, 1-3C alkylamino or di(1-3C alkyl)amino; or, when B and C are both NH or N-alkyl also halogen, 1-3C alkyl, OH, benzoyloxy, 1-3C alkoxy, 1-3C alkylmercapto, 1-3C alkylsulphinyl, 1-3C alkylsulphonyl, SO3H, NO2, NH2, 1-3C alkylamino or di(1-3C alkyl)amino. - R2,R3=H, halogen, 1-3C alkyl, OH, 1-3C alkoxy, 1-3C alkylmercapto, 1-3C alkylsulphinyl, 1-3C alkylsulphonyl, NO2, NH2, 1-3C alkylamino, di(1-3C alkyl)amino, alkanoylamino, SO2NH2, mono- or di(1-3C alkyl)aminosulphonyl, CN, COOH, (1-3C alkoxy)carbonyl, CONH2, or (1-3C alkyl)aminocarbonyl.