摘要 |
1,4-Dihydropyridine -3-phosphonates of formula (I): R1 and R2 = H, 1-10C aliphatic and/or cyclic hydrocarbyl (with 0-4 unsatd. bonds and/or opt. substd. by halogen and/or alkoxy) or opt. alkyl-substd. tetrahydrofurfuryl; R3 = lower alkyl; R4 = H, 1-10C aliphatic and/or cyclic hydrocarbyl (with 0-4 unsatd. bonds and/or opt. substd. by alkoxy, aryloxy, aralkoxy, NH2 or alkylamino), CHR9(CH2)mX(CH2)pPh or (CH2)nQ; where X = NR8 or O; R8 = lower alkyl or alkenyl; R9 = H, alkyl or opt. alkyl-substd. phenyl; p = 0-2; m = 1-4; n = 0-2; Q = 1-(CH2)pPh-piperidinyl R5 = lower alkyl; Ar = phenyl opt. substd. by 1 or 2 of NO2, CN, CF3, halogen, N3, alkoxycarbonyl, CONH2, SO2NH2, alkylsulphonyl and OCHF2.
|