NOVEL VITAMIN D3 DERIVATIVES AND PROCESS FOR PRODUCING THE SAME

摘要

There are disclosed 6,19-epidioxyvitamin D3 derivatives which are represented by the formula wherein R1, R2 and R3 are each a hydrogen atom or a hydroxyl group; when R1 is a hydrogen atom, R2 represents a hydroxyl group and R3 is a hydrogen atom or a hydroxyl group; when both R1 and R2 represent a hydroxyl group, R3 is a hydrogen atom or a hydroxyl group; and when R1 is a hydroxyl group and R2 is a hydrogen atom, R3 represents a hydroxyl group. The compounds are highly capable of inducing differentiation of human myeloid leukemia cells with minimum effects on calcium metabolism and are useful as an agent to treat leukemia.