| 摘要 |
4-Substituted proline derivatives having the formula <IMAGE> can be prepared by reacting the compound having the formula <IMAGE> with a compound having the formula <IMAGE> to obtain a compound having the formula <IMAGE> (a novel intermediate), alkylating that compound to obtain a compound having the formula <IMAGE> (a novel intermediate), converting that compound to a compound having the formula <IMAGE> (a novel intermediate), and oxidizing that compound to yield the desired proline having the formula <IMAGE> wherein R1 is alkyl, cycloalkyl, aryl or arylalkyl, R1' is alkyl, cycloalkenyl, aryl or arylalkyl, R2 is alkyl, aryl, arylalkyl or cycloalkyl and R3 is hydrogen, alkyl, aryl, arylalkyl or cycloalkyl.
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