| 摘要 |
NEW MATERIAL:A compound of formula I [one of A, B is N, the other is C; R1 is lower alkylene, lower alkenylene, single bond; T2 is lower alkylene, carbonyl, single bond; X is formula II, >N-N6 (R6 is H, lower alkyl, -S-, -S(O)-); Y is O, S; Z is >N-R7 (R7 is H, lower alkyl); R1, R5 are lower alkyl, lower alkenyl; R2 is aryl(oxy), 5-6-membered unsaturated heterocyclic ring; R3 is aryl, pyridyl; R4 is H, cyano, carbamoyl]. EXAMPLE:1,4-Dihydro-2,6-dimethyl-3-(3-piperidinomethyl-1,2,4-o-xadiazo l-5-yl)-4-phe nylpyridine-5-carboxylic acid methyl ester. USE:Preventive or remedy for hypertension, stenocardia, myocardiac infarction and arteriosclerosis. PREPARATION:The reaction of a compound of formula III, an aldehyde of formula III and an enamine of formula IV gives a compound of formula I (Z is >N-R7). |
