| 摘要 |
NEW MATERIAL:The novel antibiotic substance SF-2370 having the following properties. Appearance, neutral crystalline substance having pale yellow color; elemental analysis, C 69.50%, H 4.74%, N 8.88%; molecular formula, C27H21N3O5 [molecular weight is 467 (mass analysis, FD-MS)]; melting point, 256 deg.C; specific rotation, [alpha]D<25>=+57 deg. (C 0.1, methanol); color reactions, positive to Greig- Leaback reagent, and negative to ninhydrin and ferric chloride reagents; solubility, soluble in pyridine, dimethyl-formamide, dimethyl sulfoxide, methyl cellosolve and chloroform, hardly soluble in methanol and ethyl acetate, and insoluble in water and n-hexane. USE:Antibacterial and antifungal agent. PREPARATION:A microbial strain belonging to Actinomadura genus and capable of producing SF-2370 substance is cultured, and the objective antibiotic substance SF-2370 is separated from the culture product. |
