| 摘要 |
1-(N-(1-carboxy 3-phenylpropyl) L-lysyl)L-proline of formula (I) is made by (a) hydrogenating the benzyl ester of 1-(N-(1-benzyl oxycarbonyl 3-oxo 3-phenylpropyl) N-(benzyl oxycarbonyl)L-lysyl) L-proline of formula (II) at 20-50 deg. C in organic solvent, e.g. ethanol, isopropanol, acetic acid, using Pt or Pd/C as catalyst, to obtain (I) or its acceptable salts; and (b) isolating (I) by chromatography and fractional crystallisation.
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