| 摘要 |
NEW MATERIAL:The compound of formula I (R1 and R2 are H or lower alkyl; R3 is residue of nitrogen-containing hetero-ring) and its salt. EXAMPLE:5-Methyl-6-(4-quinolinyl)2-2H-1, 4-thiazin-3(4H)-one. USE:Remedy for cardiopathy. It increases the myocardial systole, and has low acute toxicity. PREPARATION:The objective compound can be prepared by reacting the compound of formula II [e.g. 5-methyl-2H-1, 4-thiazin-3(4H)-one, etc.] with the compound of formula AX' [A is CXnH3-nCH2OCO (X is halogen; n is 1-3); X' is halogen other than X] (e.g. 2,2,2-trichloroethyl chloroformate) and the compound of formula R3H (e.g. quinoline) preferably for 1-7hr, and reacting the resultant compound of formula III (R3' is dihydro residue of nitrogen-containing hetero-ring) with sulfur preferably at 140-180 deg.C for 1-5hr. |
