| 摘要 |
PURPOSE:To obtain the titled phospholipid useful as an emulsifier and in the medical and pharmacological fields, etc., easily in high yield, using only small amount of fatty acid and catalyst, by reacting a glycerophosphorylcholine, etc. with a fatty acid and a carbodiimide condensation agent in the presence of a catalyst. CONSTITUTION:The objective phospholipid of formula II can be prepared according to the reaction formula, by reacting (A) glycero-phosphorylcholine of formula I or its salt with (B) a fatty acid of formula RCOOH (R is aliphatic chain) and (C) a carbodiimide condensation agent [e.g. N, N'-dicyclohexylcarbodiimide (DCC), etc.] in the presence of a catalyst [e.g. 4-dimethylaminopyridine (DMAP)] in anhydrous solvent such as dichloromethane, usually at normal temperature for 6-72hr under stirring. The amount of the component C is >=1 mol per 1 mol of the component B. The component B is preferably a 10-24C fatty acid such as palmitic acid, and if necessary, a fatty acid having polymerizable group. The condensation agent may be added at a proper stage during the reaction. |
