DEVELOPMENT AND SECRETION IN BACILLUS

摘要

A novel method for expressing and secreting a functional polypeptide in Bacillus, including the vectors and transformants for the practice thereof, is provided. The vectors comprise the transcriptional and translational activity sequence, and optionally the signal peptide coding sequence, of the Staphylococcus aureus nuclease gene. The vectors and transformants are useful for the production and secretion of human hormones such as human proinsulin.