Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

摘要

A group of new daunorubicin and doxorubicin derivatives is disclosed. Included in this group are 3'-deamino-3'(3''-cyano-4''-morpholinyl doxorubicin; 3'-deamino-3'-(3''-cyano-4''-morpholinyl)-13-dihydoxorubicin; (3'-deamino-3'-(3''-cyano-4''-morpholinyl) daunorubicin; 3'-deamino-3'-(3''-cyano-4''-morpholinyl)-3-dihydrodaunorubicin; and 3'-deamino-3'-(4''-morpholinyl-5-iminodoxorubicin and derivatives thereof which have excellent activity as antitumor agents.