6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives

摘要

6,11-Dihydrodibenz[b,e]oxepin-acetic acids and derivatives having the general formula <IMAGE> are prepared by multi-step sequences. X is C=O, CHCl, CHBr, CH2 or CHOR4; Y is alkyl or alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; n is 0, 1, 2 or 3; Z is COOR5, CH2OR5, CONR25 or CONHOR5; and R1-R5 are hydrogen or alkyl of 1 to 4 carbon atoms. These compounds and the physiologically tolerable salts thereof are useful as antiinflammatory and analgesic agents.