摘要 |
A water-soluble complexes ofα-6-deoxy-5-hydroxytetracycline (I) and Na tetrametaphosphate was prepd. from I. Thus, fleshly prepd. 4.33g of (HPO3)n (n=4) was treated with 1 ml of H2O and 20g of I H2O and later with 0.574g of NaOH in MeOH. After adding iso-PrOH, the growing cryst. compd. was filtered, washed, dried to give 21g of I and Na (HPO3)n (n=4) complexes. The major advantage of using this complexes is its decreased interference in the action in human serum of natural bactericides. The bioavailability of this complexes (4.32μg/ml/3h) was higher than that of I capsules.
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