| 摘要 |
New peptides of the formula I X-Z-NH-CHR-CHOH-CH2-CO-NH-CHR1-CH2-NH-CHY-CnH2n-R2 I in which X is H, R3-O-CH2-CO-, R3-O-CO-, R3-CH2-O-CO- or R3-CmH2m-CO-, Z is 1 to 4 aminoacid residues which are bonded together in the manner of peptides and are selected from the group comprising Abu, Ala, Arg, Asn, Dab, Gln, Gly, His, Ile, Leu, Lys, Met, NLeu, Orn, Phe, Pro, Trp, Tyr and Val, is A, Ar-alkyl (in which the group -alkyl contains 1-4 C atoms) or cycloalkyl-alkyl having 4-11 C atoms, R1 is H or A, Y is H, A, -CpH2p-OR4, -CpH2p-NHR4, -COOR4, -CONHR4 or -CONA2, R2 is A, cycloalkyl having 3-7 C atoms, Ar, pyridyl, indolyl, imidazolyl, piperidyl, N-benzylpiperidyl or piperazinyl, R3 is A, cycloalkyl having 3-7 C atoms or Ar, R4 is H, A or cycloalkyl having 3-7 C atoms, A is alkyl having 1-6 C atoms, Ar is phenyl which is unsubstituted or substituted once or several times by A, AO, F, Cl, Br, I, CF3 and/or NH2, or is unsubstituted naphthyl, and m, n and p each are 0, 1, 2, 3, 4 or 5, and their salts inhibit the activity of the renin in human plasma. |
