1-(Aminoalkyl)-alpha, alpha-diaryl pyrrolidine-piperidine- and homopiperidine- acetamides and acetonitriles.

摘要

1-(Aminoalkyl)- alpha , alpha -diaryl pyrrolidinyl, piperidino and homopiperidinoacetamides and acetonitriles having the formula <CHEM> wherein: n is 0, 1 or 2; Ar<1> and Ar<2> are 2, 3 or 4-pyrido, phenyl or substituted phenyl; Y is aminocarbonyl or cyano; x is 2 to 5; R is H or loweralkyl; R<1> and R<2> are hydrogen, cycloalkyl, loweralkyl, and R<2> and R<3> taken with the adjacent nitrogen may form a heterocyclic residue (including their diastereoisomers when possible) and pharmaceutical salts; have cardiac antiarrhythmic activity. r