1-[(Aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl]-alpha,alpha-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles.

摘要

1-(Aminoalkyl and aminoalkylamino) carbonyl and thiocarbonyl- alpha , alpha -diaryl-pyrrolidine, piperidine and homopiperidineacetamides and acetonitriles having the formula:

wherein:
n is zero, one or two;
X is oxygen or sulphur;
Z is

p is 0 to 5 inclusive with the proviso that when Z is

p is at least one;
Y is aminocarbonyl or cyano;
Ar<1> and Ar<2> are 2,3 or 4-pyrido, phenyl or substituted phenyl;
R is hydrogen or loweralkyl;
R<1>, R<2> and R<3> are hydrogen, cycloalkyl, loweralkyl, phenyl, substituted phenyl, phenyl-loweralkyl, and R<2> and R<3> taken with the adjacent nitrogen may form a heterocyclic residue, (including diastereoisomers when possible) and pharmaceutical salts; are disclosed as having cardiac antiarrhythmic activity.