发明名称 |
Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one |
摘要 |
The compound 6(R)-[2-8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S), 5,6,7,8,8a(S)-decahydronaphthyl-1(S)ethyl]-4(R)-hydroxy-3,4,5,6-tetrah ydro-2H-pyran-2-one is prepared in two steps from mevinolin and comprise reduction of the two double bonds and C-methylation of the 8(S)-(2-methylbutyryloxy) group to form the 2,2-dimethylbutyryloxy group. The two steps can be performed in either order.
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申请公布号 |
US4584389(A) |
申请公布日期 |
1986.04.22 |
申请号 |
US19850737361 |
申请日期 |
1985.05.23 |
申请人 |
MERCK & CO., INC. |
发明人 |
SLETZINGER, MEYER;VERHOEVEN, THOMAS R.;VOLANTE, RALPH P. |
分类号 |
C07D309/30;(IPC1-7):C07D309/10 |
主分类号 |
C07D309/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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