发明名称 Antithrombotic 4,5 di-t-butyl-imidazole derivatives
摘要 Imidazole derivatives of the formula <IMAGE> I wherein X is hydrogen or C1-4-n-alkyl and Y is thienyl, optionally substituted by methyl or fluorine, or a group of the formula <IMAGE> Y1 wherein R1, R2 and R3 independently are hydrogen, methyl, fluorine, hydroxy or methoxy, or two of R1, R2 and R3 on adjacent carbon atoms taken together are methylenedioxy or ethylenedioxy, or one of R1, R2 and R3 is mono- or di-(C1-4-n-alkyl)-amino and the other two are hydrogen, and physiologically compatible or pharmaceutically acceptable acid addition salts thereof, are described. These compounds of formula I inhibit the aggregation of the blood platelets.
申请公布号 US4582844(A) 申请公布日期 1986.04.15
申请号 US19850774393 申请日期 1985.09.10
申请人 HOFFMANN-LA ROCHE INC. 发明人 DERUNGS, ROMANO
分类号 A61K31/415;A61P7/02;C07D233/54;C07D233/58;C07D233/64;C07D405/04;C07D409/04;C07D495/04;(IPC1-7):A61K31/415;C07D405/10 主分类号 A61K31/415
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