| 摘要 |
Compounds of the formula <IMAGE> wherein A is benzo, mono-, di- or tri-substituted benzo, the substituents being selected from the group consisting of lower alkoxy, amino and nitro, or pyrido; R1 is hydrogen or lower alkyl; R2 is alkyl of 1 to 6 carbon atoms or -X-R6, where X is straight alkylene of 1 to 4 carbon atoms or hydroxy-substituted straight alkylene of 1 to 4 carbon atoms; and R6 is amino; carbalkoxy of 2 to 6 carbon atoms; phenyl; mono-, di- or tri-substituted phenyl, the substituents being selected from the group consisting of lower alkyl and lower alkoxy; phenoxy; or mono-, di- or tri-substituted phenoxy, the substituents being selected from the group consisting of lower alkyl and lower alkoxy; R3 is hydrogen or hydroxyl; R4 is hydrogen, lower alkyl or lower alkoxy; R5 is hydrogen or lower alkyl; and N IS 0, 1 OR 2; AND NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF. The compounds as well as the salts are useful as antiarrhythmics, beta -adrenergic-receptor blockers and anti-anginous agents. |
