发明名称 |
TRICYCLIC ANTIDEPRESSANT DRUG IMMUNOGENS, ANTIBODIES, LABELED CONJUGATES, AND RELATED DERIVATIVES |
摘要 |
<p>Tricyclic antidepressant drug (e.g., imipramine, desipramine, amitriptyline, or nortriptyline) immunogens, antibodies prepared therefrom, labeled conjugates, synthetic intermediates, and the use of such antibodies and labeled conjugates in immunoassays for determining such drug. The immunogens comprise the drug coupled at its 2'-position to an immunogenic carrier material. Similarly, the labeled conjugates and synthetic intermediates are 2'-derivatives of the drug or a precursor thereof. The antibodies and labeled reagents are particularly useful in certain homogeneous nonradioisotopic immunoassays for measuring tricyclic antidepressant drugs in biological fluids such as serum.</p> |
申请公布号 |
EP0107134(B1) |
申请公布日期 |
1986.04.09 |
申请号 |
EP19830110063 |
申请日期 |
1983.10.08 |
申请人 |
MILES LABORATORIES, INC. |
发明人 |
BUCKLER, ROBERT THOMAS;WARD, FREDERICK EDMUND |
分类号 |
G01N33/53;C07D223/22;C07D303/14;C07D405/06;C07H17/075;C07H21/00;C07K14/435;C07K14/76;C07K16/00;G01N33/532;G01N33/94;(IPC1-7):G01N33/532;C07C93/00;C07D223/28;C07H17/06;C07K17/00;C07H21/02 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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