发明名称 |
COMBINED HAEMOPHILUS INFLUENZAE AND DIPHTHERIA, PERTUSSIS, TETANUS VACCINE |
摘要 |
A vaccine for eliciting polyribosyl ribitol phosphate (PRP) antibody formation in a warm-blooded animal has been invented. The vaccine comprises the capsular polysaccharide PRP isolated and purified from Haemophilus influenzae type b combined with a diphtheria, Bordetella pertussis and tetanus (DPT) vaccine. A method of making a vaccine for eliciting polyribosylribitol phosphate (PRP) antibody formation in a warm-blooded animal has also been invented. The method of making comprises obtaining purified PRP; dissolving the PRP in phosphate buffered saline solution having a pH of about 7.0; sterile filtering the PRP solution; and combining the PRP solution with a diphtheria, B. pertussis and tetanus vaccine. Finally, a method for inducing active immunization in a warm-blooded animal against systemic infection caused by the pathogen H. influenzae type b has been invented. The method of using comprises administering an immunogenic amount of a vaccine comprising the capsular polysaccharide polyribosyl ribitol phosphate (PRP) isolated and purified from H. influenzae type b combined with a diphtheria, B. pertussis and tetanus (DPT) vaccine. |
申请公布号 |
EP0101562(A3) |
申请公布日期 |
1986.04.09 |
申请号 |
EP19830107024 |
申请日期 |
1983.07.18 |
申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
KUO, JOSEPH S.C. |
分类号 |
A61K39/05;A61K39/08;A61K39/095;A61K39/102;A61K39/116;(IPC1-7):A61K39/02;A61K39/10 |
主分类号 |
A61K39/05 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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