PIPERAZINE DERIVATIVE AND PROCESSES FOR PREPARING THE SAME

摘要

PIPERAZINE DERIVATIVE AND PROCESSES FOR PREPARING THE SAME The invention relates to a piperazine derivative of the formula: < IMG > (I) wherein R1 is hydrogen, alkyl (C1-8), alkyl (C1-4)-sulfonyl or an acyl group of the formula: R CO- (wherein R3 is hydrogen, alkyl (C1-7), halogenoalkyl (C1-4), alkoxy (C1-4)- carbonyl-alkyl (C1-4), cyclalkyl (C3-6), alkenyl (C2-5)- alkoxy (C1-4), amino, alkyl (C1-4)-amino or anilino), R2 is hydrogen, alkyl (C1-4), alkoxy (C1 4)-carbonyl-alkyl (C1-4), carboxy-alkyl (C1-4), alkenyl (C2-5) or alkyl (C1-4)-sulfonyl, or R1 and R2 are combined together to form succinyl group, Ring A is phenyl, alkyl (C1-4)-phenyl or halogenophenyl, and n is an integer of 2 to 6, or a pharmaceutically acceptable acid addition salt thereof. The piperazine derivative (I) has an intracranial pressurelowering activity, and also has a depressing effect on central nervous system.