| 摘要 |
<p>PURPOSE:N-(1-Cyclohexenyl-3-one)-aspartic acid is treated with a dehydrating agent in a solvent, then allowed to condense with a phenylalanine ester and the amino-protecting group is eliminated to give the titled compound used as a sweetening with industrial advantage. CONSTITUTION:The amino group in aspartic acid is protected with cyclohexane-1,3-dione using a dehydration agent to give potassium N-(1- cyclohexenyl-3-one)-aspartate. The product is treated with a dehydration agent such as acetic anhydride in a mixed solvent of acetic acid and ethyl acetate. Then, phenylalanine ester is added to the system to effect dehydration reaction and hydrochloric acid is added to eliminate 1-cyclohexenyl-3-one, thus giving the objective compound.</p> |
