| 摘要 |
NEW MATERIAL:A compound shown by the formula I [X is OH, lower alkoxy, lower alkylthio, aralkyloxy, etc.; Y is H, or halogen; R1 is 3-15C alkylene, or alkenylene; Z is CH2OH, lower alkoxymethyl, lower alkylsulfonylmethyl, CH2NHR2 (R2 is lower alkyl, etc.), iminomethyl, halogen, etc.] and its salt. EXAMPLE:4-Benzyloxy-2-(11-t-butyldimethylsilyloxyundecyl)quinoline-N-o xide. USE:A remedy and a preventive for bronchial asthma, allergosis, ischemic cardiac disease, hypertension, ischemic cerebral disorder, arteriosclerosis, etc. PREPARATION:A compound shown by the formula II is reacted with a Grignard reagent shown by the formula t-Bu(Me)2SiOCH2R1MgHgl to give a compound shown by the formula III, which is hydrolyzed with hydrochloric acid, etc. in a solvent such as a alcohol, etc. to give a compound shown by the formula IV. |
