| 摘要 |
<p>The synthesis of 5,6-dioxy substituted quinazolinediones is described. The novel quinazolinediones are useful as cardiotonic agents, and have the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="27" wi="43" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R, and R<Sub>2</Sub> are the same or different substituents and are hydrogen, lower alkyl or methylenedioxy when taken together; Y and Z are the same or different and are hydrogen, nitro, amino, acetamido, alkylamino,alkyl, cycloalkylamino and cycloalkyldiamino, carboxy, carboalkoxy, cyano, methanesulfonyl, carboxamido and halo; R<Sub>3</Sub> is hydrogen, alkyl, hydroxylakyl, haloalkyl, amino, dialkylamino, dialkylamino alkyl, cycloalkylamino, cycloalkylaminoalkyl, phenyl, substituted phenyl; R<Sub>4</Sub> is hydrogen, lower alkyl, carboalkoxy and wherein R<Sub>6</Sub> is hydrogen or lower alkyl; X is carboxyl, carboalkosy, cyano, carboxamido, methanesulfonyl, formyl, benzoyl and substituted benzoyl and the pharmaceutically acceptable salts thereof; provided that when R<Sub>3</Sub> is amino or alkylamino, Y and Z are not simultaneously hydrogen.</p> |
