| 摘要 |
<p>The invention relates to novel water-soluble mixed ethers of beta -cyclodextrin ( beta -CD) with ether substituents comprising (C1 and C2) alkyl, hydroxy(C2 to C4)alkyl and carboxy(C1 and C2)alkyl such as methylhydroxyethyl- beta -CD or hydroxyethyl-carboxy-methyl- beta -CD; hydroxyethyl-hydroxy propyl ethers are excepted. The process of the invention comprises reacting beta -cyclodextrin with at least two different alkylating, hydroxyalkylating and/or carboxyalkylating etherifying agents (for example, methyl chloride, ethylene oxide and/or chloroacetic acid) in a basic, liquid reaction medium containing an alkali-metal hydroxide, water and, optionally, at least one organic solvent (for example, dimethoxyethane or isopropanol).</p> |
