发明名称 Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents
摘要 Compounds of the structure <IMAGE> and pharmaceutically acceptable salts thereof, wherein: R1 and R2 are independently H, OH, lower alkyl, lower alkoxy, aryloxy, heteroaryloxy, heteroaryl lower alkoxy, aryl, heteroaryl, aryl-lower alkyl, aryl-lower alkoxy, halogenated aryl-lower alkoxy, lower alkenyl, lower alkynyl, lower alkenoxy, lower alkynoxy, halogen or trifluoromethyl; A is H, aryl, lower alkyl, aryl-lower alkyl or heteroaryl; and B is <IMAGE> n=0-6, wherein D is H, CONR3R4, CO2H, CO2R5, CH2OH or CH2OR6, wherein R3, R4, R5 and R6 are independently H, lower alkyl, aryl, aryl-lower alkyl or heteroaryl; E is H, OH, lower alkyl, aryl or heteroaryl; and F is <IMAGE> wherein G is the same as R1 and R2, useful for the treatment of allergy, asthma and inflammatory conditions.
申请公布号 US4579866(A) 申请公布日期 1986.04.01
申请号 US19840614579 申请日期 1984.05.29
申请人 USV PHARMACEUTICAL CORP. 发明人 STEVENSON, DAVID;LIU, ROBERT C.;HO, LAURENCE L.;JONES, HOWARD;COUTTS, STEPHEN
分类号 C07D215/14;A61K31/165;A61K31/195;A61K31/215;A61K31/22;A61K31/403;A61K31/404;A61K31/405;A61K31/47;A61P11/08;A61P29/00;A61P37/08;A61P43/00;C07C67/00;C07C231/00;C07C233/11;C07C233/17;C07C233/45;C07C233/65;C07C233/68;C07C233/81;C07C235/32;C07C235/48;C07D209/20;C07D521/00;(IPC1-7):A61K31/24;C07C101/04 主分类号 C07D215/14
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