DIHYDROPYRIDINES, METHODS FOR THEIR PRODUCTION AND THEIR FORMULATION AND USE AS PHARMACEUTICALS

摘要

There are described compounds of formula I, in which X is oxygen or sulphur, R1 and R2, which may be the same or different, each represent alkyl C 1 to 6, -(CH2)n OR5, or -(CH2)n NR6R7, and in addition R2 may represent hydrogen, n is a whole number from 2 to 4 inclusive, R3 represents -CH2OH, -CN, -CH(OR4)2, -CHO, -CH=NOH, -CF3, or, together with R2 forms a chain -CHOH-, R4 represents alkyl C 1 to 6, R5 represents alkyl C 1 to 6 or phenyl, R6 and R7, which may be the same or different, each represent alkyl C 1 to 6 optionally substituted by phenyl, and R8 is alkyl C 1 to 6, and pharmaceutically acceptable acid addition salts of those compounds containing a basic nitrogen atom. There are also described methods for making the compounds and pharmaceutical, e.g. cardiac, compositions containing them.