PROCESS FOR PRODUCING MITOMYCIN A BY FERMENTATION

摘要

A process for producing mitomycin A by fermentation, which involves culturing a microorganism belonging to the genus Streptomyces, (and particularly the strains of Streptomyces caespitosus AN-9 (NRRL 12513) and T-17-135 (NRRL 12508)), which is capable of producing mitomycin A and having at least one property of (1) deficiency in an ability to produce mitomycin C and (2) a resistance to tryptophan analog, in a culture medium forming and accumulating mitomycin A in the culture medium; and recovering mitomycin A therefrom.