| 摘要 |
<p>Prostaglandin thia analogues of formula (I) (where A is CO or CHOH; B is CH2CH2 or CH=CH; R1 is H or 1-4C alkyl; m is 0-5; n is 0-3, and may also be 4-9 when B is CH=CH; R2 is 1-4C alkoxy, phenoxy, pyridyl, thienyl, naphthyl, phenyl, substd. by F, Cl, Br, OH, OCH3, or CF3, or phenoxy substd. by F, Cl, Br, OH, OCH3, CH3 or CF3, and may also be H, phenyl or tolyl when b is CH=CH; and indicates that configuration may be alpha or beta) e.g. 11, 15-dihydroxy-16-(p-fluorophenoxy)-15-methyl-9-oxo-17,18,19,20-tet- ranor-13-thiaprostanoic acid, and their physiologically innocuous salts are new cpds. (I ) have hypotensive activity (as shown when infused into cats under barbiturate anaesthesia) as well as vasodilatory, anti-inflammatory, diuretic, anti-bronchospasm, gastric secretion inhibitory, thrombocyte aggregation inhibitory, lipid breakdown inhibitory, noradrenaline release inhibitory and nasal mucosa contracting props. They also have effects on the corpus luteum, egg transport through the oviduct, nidation and fertility. (I) are also useful as inters. for other pharmaceuticals.</p> |
