| 发明名称 |
An improved process for cephalosporin intermediates. |
| 摘要 |
<p>7 beta -Amino-3-(1-pyridiniummethyl)-3-cephem-4-carboxylate dihydrochloride salt is obtained as the crystalline dihydrate directly from the N-deacylation reaction mixture by mixing said reaction mixture with acetonitrile, acetone or isopropyl alcohol, each containing 5% to 10% water.</p> |
| 申请公布号 |
EP0175544(A2) |
申请公布日期 |
1986.03.26 |
| 申请号 |
EP19850306449 |
申请日期 |
1985.09.11 |
| 申请人 |
ELI LILLY AND COMPANY |
发明人 |
CHOU, TA-SEN;HOYLING, RICHARD CHARLES;LAKIN, ROBERT EUGENE;YANG, KUO SHANG |
| 分类号 |
C07D;C07D501/04;C07D501/18;C07D501/38;C07D501/48;(IPC1-7):C07D501/18 |
主分类号 |
C07D |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
