发明名称 |
DELIVERY DEVICE FOR ZERO-ORDER RELEASE OF AN ACTIVE PRINCIPLE INTO A DISSOLUTION FLUID AND PROCESS FOR ITS PREPARATION |
摘要 |
A delivery device for zero-order release of an active principle into a dissolution fluid includes a reservoir consisting of a solid matrix of a homogeneous mixture of a polymer material, at least a portion of the active principle and an additive soluble in the dissolution fluid with negative heat of solution, a coating on the solid matrix-type reservoir of a first, release rate-controlling insoluble membrane which modulates the active principle release according to the desired kinetics; and a second, protective membrane on the release rate-controlling membrane of a soluble polymer material. |
申请公布号 |
ZA8505553(B) |
申请公布日期 |
1986.03.26 |
申请号 |
ZA19850005553 |
申请日期 |
1985.07.23 |
申请人 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. |
发明人 |
PAOLO COLOMBO;UBALDO CONTE;ALBERTO REINER |
分类号 |
A01N25/00;A61K9/00;A61K9/24;B01J4/04 |
主分类号 |
A01N25/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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